Blar i forfatter "Ghelue, Marijke van"

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    • BAFF expression is increased in Lupus Nephritis and associated with activation of C1 inhibitor, α-1-acid-glycoprotein and endothelial markers. 

      Eilertsen, Gro Østli; Ghelue, Marijke van; Nossent, Johannes C (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      B cell activating factor (BAFF) inhibitor therapy has recently been approved for non-renal Systemic Lupus Erythematosus (SLE). While BAFF plays a role in experimental lupus nephritis (LN), its role human LN is not well studied. Case control study in 102 SLE patients, 30 with LN (+LN) and 72 without LN (-LN) and 31 healthy controls. We analysed BAFF mRNA expression in PBMCs (BAFF-RQ) and serum BAFF ...

    • Functional analyses of rare germline BRCA1 variants by transcriptional activation and homologous recombination repair assays 

      Bassi, Nicola; Hovland, Henrikke Nilsen; Rasheed, Kashif; Ghelue, Marijke van (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-21)
      Background - Damaging alterations in the BRCA1 gene have been extensively described as one of the main causes of hereditary breast and ovarian cancer (HBOC). BRCA1 alterations can lead to impaired homologous recombination repair (HRR) of double-stranded DNA breaks, a process which involves the RING, BRCT and coiled-coil domains of the BRCA1 protein. In addition, the BRCA1 protein is involved in ...